We are seeking for a highly motivated and experienced scientists for a managerial and subject matter expert position in the prediction of pharmacokinetics and in vitro drug-drug interactions (DDI) to join the Drug Interactions and In Vitro Technology (DIIVT) team, within the Drug Metabolism and Pharmacokinetics Department (DMPK). DMPK department is part of the Translational Medicine organization of Servier R&D located at the Servier Paris Saclay Research&Development Institute.

The DMPK unit plays a major role in the research and development strategy for new drugs via i. Supporting the early optimization and selection of drug candidates, ii. Accelerating entry into clinical phase I, iii. Providing DMPK knowledge at all stages of drug candidate development. The DIIVT team aims to predict the DMPK and DDI profile of new drug candidates, from the early stages of drug discovery to the post-marketing phase.

The successful candidate will be responsible for the managerial supervision of a team of technicians as well as the coordination, planning, implementation, monitoring, interpretation and reporting of in vitro pharmacokinetic and drug interactions studies covering all stages of drug discovery and development in close collaboration with the other teams of the DMPK department. 

The position is mainly focused on studies to predict the pharmacokinetic parameters of new molecules in the early stages of research with the aim of selecting new drug candidates. The candidate must demonstrate adaptability, responsiveness and respect for the short deadlines associated with this type of activity.
 

Activities :

• Planning and implementation of studies, monitoring, interpretation and writing of reports according to regulatory and internal requirements. 
• Allocation of human, material and time resources to carry out the studies for which he/she is responsible as well as for those of the DIIVT platform.
• Animation, motivation and development of the experimentalist team
• Prediction of the risks of drug interactions related to the pharmacokinetics of drug candidates for the early clinical phases.
• Responding to questions related to drug interactions from Health Authorities
• Communication of the study results to the representatives of the discipline, raising alerts having an impact on the course of the study (deadline, cost, modifications) and proposing solutions. 
• Scientific support for the subcontracted studies and the evaluation of new subcontractors in close collaboration with the externalization team.
• Take charge of several projects and collaborate cross-functionally with colleagues in the department and from other Poles of Activity of the Saclay Research Institute.
• Following scientific, technical and regulatory developments (Bibliography, Congress etc.). Implement new tools and/or technologies to extend the capabilities and improve the efficiency of in vitro   predictions of pharmacokinetics and drug-drug interactions.
• Compliance with health and safety rules (laboratory and IT) in force at the Institute.
• Regularly update the operating procedures (SOP) according to the good level of quality defined and technical-scientific knowledge
• Participation in the functioning of the department (maintenance, technical working groups, etc.).

Description du profil :

• Rigor, ability to synthesize data, good organization, autonomy, reactivity, multi-skills, good written and oral communication, team spirit, good managerial skills, proactive, able to adapt and work in a constantly changing environment, prone to innovation.
• The candidate should possibly have a minimum of 3 years of experience in in vitro assays for drug development in the field of DMPK.
• Recognized leadership skills and/or strong affinity for managing scientists.
• Solid training and experience in pharmacokinetics interpretation and drug interaction predictions as well as theoretical knowledge of the pharmacokinetics area, i.e. metabolic enzymes, drug transporters and their regulatory proteins, enzymology, cell biology and analytical chemistry ( H/UPLC coupled with mass spectrometry).
• Practical experience of in vitro cellular and/or subcellular techniques (culture, incubation) specific to studies aimed at predicting the risks of drug interactions and the pharmacokinetics of drugs and drug candidates.
• Good knowledge of the regulations around these studies.
• Mastery of office IT tools (XLS, Word, PowerPoint) and interpretation software (eg: GraphPrism, etc.)
• Fluent English