Post-doctoral fellow in Single Cell Proteomics

Are you a dynamic and innovative researcher passionate about advancing cancer treatment? We are seeking a post-doctoral fellow to join our oncology drug discovery team, focusing on single-cell proteomics (SCP). This is a unique opportunity to play a crucial role in analyzing protein expression at the individual cell level to understand tumor heterogeneity, integrating SCP with single-cell transcriptomics (SCT) for a comprehensive view of cellular mechanisms. Your work will drive drug discovery, identify new therapeutic targets, develop targeted therapies, and optimize treatment regimens.

Why Join Us?

Impactful Research: SCP is transforming pharmaceutical research, particularly in oncology, by analyzing protein expression profiles at the individual cell level. This approach is crucial for understanding cellular heterogeneity within tumors, which traditional bulk proteomics often overlooks. Integrating SCP with SCT in a single-cell multi-omics framework offers a holistic understanding of cellular mechanisms, enhancing the discovery of therapeutic targets and biomarkers.

Innovative Environment: Lead efforts to implement advanced single-cell analysis using cutting-edge instruments for precise cell isolation and HR-MS for proteome differential analysis. Make a significant impact in oncology by addressing critical unmet medical needs.

Collaborative Team: Work alongside cross-functional teams to ensure alignment and integration of research efforts with broader organizational goals.

Responsibilities:

• Design and execute experiments in single-cell proteomics and single-cell transcriptomics.
• Develop and optimize protocols for sample preparation, data acquisition, and analysis.
• Analyze proteomic and transcriptomic data using bioinformatics tools.
• Interpret results to draw meaningful conclusions and inform subsequent experiments.
• Collaborate with other researchers and interdisciplinary teams to advance research projects.
• Provide expertise and support to team members in proteomics and bioinformatics.
• Mentor and supervise graduate students and junior researchers.
• Provide training in experimental techniques and data analysis.
• Write and publish research findings in peer-reviewed scientific journals.
• Present research results at international conferences and seminars.

Description du profil :

Profile:

• Ph.D. in biochemistry, molecular biology, biotechnology, or a related field, with a specialization in proteomics.
• Mastery of proteomics techniques, including mass spectrometry, proteomic data analysis, and protein separation methods.
• Expertise in Single Cell Proteomics, including sample preparation, data analysis, and result interpretation.
• Bioinformatics skills for multiomics data analysis, including single-cell transcriptomics.
• Knowledge of bioinformatics software and tools commonly used in proteomics and transcriptomics.
• English is required; French is a plus.
• Experience in supervising and training master’s students.
• Excellent communication skills, both written and oral, for writing scientific publications and presenting research results.
• Ability to work in a team and collaborate with researchers from various disciplines.
• Problem-solving and critical thinking skills to overcome experimental and analytical challenges.
• Flexibility and adaptability to adjust to technological and methodological advancements in the field of proteomics and transcriptomics.