Job Opportunity: Post-Doctoral Fellow in Oncology Drug Discovery

Are you a dynamic and innovative researcher passionate about advancing cancer treatment? We are seeking a post-doctoral fellow to join our oncology drug discovery team, focusing on hard-to-treat cancers. This is a unique opportunity to play a crucial role in replenishing our drug discovery pipeline, particularly in the early stages, by identifying novel targets and targeting cancer-specific mutations. 

Why Join Us?

Impactful Research: The tumor suppressor TP53 is the most commonly mutated gene in cancer, with mutations prevalent in 20-75% of oncology diseases and associated with poor prognosis. There are currently no targeted treatments for patients with TP53 mutations, highlighting a significant medical need and an area ripe for creative strategies.

Innovative Environment: Lead efforts to identify and target novel cancer-specific mutations, particularly those involving TP53, making a significant impact in oncology by addressing critical unmet medical needs.

Collaborative Team: Work alongside cross-functional teams to ensure alignment and integration of research efforts with broader organizational goals. 

Responsibilities :

• Develop and implement strategies for setting up 2D and 3D cultures and assay conditions to select human cell lines for cellular screening and cell painting.
• Execute primary and secondary screens to identify potential drug candidates.
• Characterize bioactive molecules to evaluate their potency, specificity, selectivity, and early signs of efficacy and toxicity.
• Conduct cellular target deconvolution to identify novel targets and develop drugs specifically targeting cancer mutations.
• Study the mechanism of action of molecules, including cell death signaling pathways.
• Collaborate with cross-functional teams to ensure research efforts align with organizational goals.
• Propose new ideas and targets based on literature or personal research findings.
• Actively follow literature on the subject.
• Present research findings at internal meetings.
• Prepare and publish protocols and scientific manuscripts under the direction of the manager.
• Comply with health and safety rules and required quality standards.

Description du profil :

Profile :

• PhD in oncology, cancer cell biology, cell biology, or biotechnology.
• Strong experience in cell biology, pharmacology, and confocal imaging.
• Prior experience in in vitro/in vivo cancer models and cancer cell signaling.
• Experience with high-throughput screening technologies and robotic platforms in 384-well format is appreciated.
• Experience in high-content screening and imaging data analysis is appreciated.
• Proven research record, including conceptual work that resulted in a first-author publication (or in the process of publishing).
• Mastery of oral and written English.
• Autonomous, proactive, rigorous, reliable, motivated, scientifically and technologically curious, and a committed team player.