Project:

Immune-related actinopathies are primary immune deficiencies (PIDs) associated with gene defects impacting actin cytoskeleton remodeling. Phenotypically, patients affected by immune related actinopathies can present with a large spectrum of clinical manifestations.

In this project we aim to better understand the pathophysiological mechanisms by which deleterious mutations in actin-related PID genes contribute to primary immunodeficiencies.

In particular we seek to characterize the impact that deleterious mutations in these genes have in different immune cell functions; and to determine the mechanisms by which alterations in cell migration could contribute to disease pathogenesis. To do so, we will leverage a biobank of primary cells and cell lines derived from patients, and a microfluidic approach to study cell migration under confinement.

The position:

We offer a challenging research project in a stimulating interdisciplinary environment.

The position is funded by the French research agency grant for a 2-year period. During this period, the successful candidate is expected to apply and secure an external fellowship.

Your profile:

• Highly motivated scientist (PhD) ;

• Creative and willing to take the initiative in the development and implementation of the project ;

• Strong interpersonal skills ;

• Solid background in immunology and cell biology ;

• Self-motivation and ability to work independently are vital ;

• Additional experience in animal experimentation, cell imaging and flow cytometry are considered a plus, but excellent applicants eager to learn these techniques in our lab will be also considered.

Your application:

Please send a motivation letter with a statement of research interest, a detailed CV with publication list and two references