We are looking for a motivated intern to quantify and characterize the genomic, transcriptomic, and functional drift of PDOs over time. You will:

• Analyze how PDOs evolve across passages

• Investigate why some lines grow faster than others

• Assess how freezing/thawing affects molecular and functional profiles

You will work closely with both the lab and data science teams and leverage existing multi-omics and functional datasets across multiple passages and PDO lines. This internship is a strong opportunity to contribute to functional precision medicine and oncology drug discovery in a highly multidisciplinary environment.

Key Responsabilities

• Explore and curate existing multi-omics and functional datasets for PDOs across passages.

• Design and implement drift metrics at genomic, transcriptomic, and functional levels.

• Perform statistical analyses and data visualization (clustering, dimensionality reduction, trajectory-like analyses, correlation with growth/response).

• Present results regularly to the computational biology and wet lab teams.

• Document your code and analyses so they can be reused by the team.

Needs to have

• BSc, MSc, MEng or any related diploma in the field of computational biology, computer science or machine learning

• Strong quantitative background and prior experience in computational biology and/or machine learning

• Genuine curiosity and energy to explore new projects

• Exceptional collaboration and communication skills

• Proficiency in English

Nice-to-Haves

• Experience in working with the modern code development toolbox

• Past experience in bioinformatics or the manipulation of genomic data is a plus

• Very good quantitative skills and a demonstrated ability to apply them in real-world environments

• Passion for the intersection of data, biology and the clinic

HR Call (15 minutes call) – An initial discussion to better understand your background, experiences, and motivations.

Technical Interview (45 minutes call) – A deep dive into your technical skills and expertise relevant to the role.

Founder Interview: As final step of our recruitment process, you will meet the CTO of Orakl Oncology in person at our office. This meeting is an opportunity for the founders to assess cultural fit and ensure alignment with our company values.