DNA Script

DNA Script

Research Scientist - Nucleoside, Nucleotide and oligonucleotide Chemistry

  • Permanent contract 
  • Starting date:  
  • Le Kremlin-Bicêtre
  • PhD
  • > 2 years

The company

DNA Script

DNA Script

    The job

    Research Scientist - Nucleoside, Nucleotide and oligonucleotide Chemistry

    • Permanent contract 
    • Starting date:  
    • Le Kremlin-Bicêtre
    • PhD
    • > 2 years

    About

    DNA Script is a leading company in manufacturing de novo synthetic nucleic acids using a proprietary enzymatic technology. DNA Script’s approach leverages nature’s billions of years of evolution in synthesizing DNA to set a new standard for how nucleic acids are made and accelerate the adoption of synthetic biology across diverse disciplines such as biopharma, sustainable chemistry and data storage. DNA Script’s first product is the SYNTAX system, the first world’s first benchtop DNA printer using enzymatic synthesis.

    To date, DNA Script has raised over $100M of financing, mostly through leading investors such as Casdin, Agilent, Danaher, LSP, Bpifrance, Illumina Ventures, Merck Ventures, Sofinnova Partners, Kurma Partners, Idinvest.

    DNA Script has its research facility headquartered in Paris, France, and has its commercial and development teams in South San Francisco.

    Job description

    The role

    The Research Scientist - Nucleoside, Nucleotide and oligonucleotide Chemistry will be a part of Chemistry R&D team focusing on the continued research and development of DNA Script’s Enzymatic DNA Synthesis (EDS) technology to enhance synthesis protocols, enable customer applications, and improve product performance. You will report to the Director of Chemistry.

    Responsibilities

    • Collaborate with all the functions within the company to improve Enzymatic DNA Synthesis performance and advance our technology
    • Design and execute synthesis of modified nucleotides with additional functionalities to broaden DNA Script’s EDS technology applications
    • Develop in-house nucleoside phosphoramidite chemistry and automated oligonucleotide synthesis capacity
    • Accurately document experiments and results in laboratory notebooks in a timely fashion
    • Prepare and present experimental plans, results, and reports in R&D meetings
    • Contribute to the development of the DNA Script patent portfolio and the scientific literature
    • Maintain good laboratory and safety practices

    Preferred experience

    Experience and skills

    Essential:

    • Holds a PhD degree in Organic Chemistry, Medicinal Chemistry or similar field with extensive training and practical laboratory experience in multi-step organic synthesis
    • Experience in nucleoside, nucleotide synthesis and purification
    • Preferred experience with nucleoside phosphoramidite chemistry and automated oligonucleotide synthesizer
    • Hands-on experience in modern isolation, purification, and analytical techniques: Flash chromatography, Analytical and preparative HPLC, LC/MS, 1H/31P NMR, UV-Vis
    • Strong publication record demonstrating ability to conduct research projects independently and collaboratively
    • Excellent written, organizational, and documentation skills
    • Excellent communication and interpersonal skills, efficient interaction with internal and cross functional team members
    • Fluent English speaker

    Miscellaneous

    • Job located in Kremlin-Bicêtre (Paris area), please submit your resume and cover letter in English with your application
    • Start date: ASAP

    Recruitment process

    • Phone interview with manager
    • Day Interview at the office with manager, cofounders, HR and the team
    • References Check
    • Timing: 2 to 3 weeks

    Meet the team

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