We are seeking a talented and rigorous analytical chemist / natural products scientist with deep hands-on expertise in the isolation, analysis, and structural elucidation of complex small molecules. This role sits at the heart of Generare’s natural product discovery pipeline, and will be instrumental in characterizing novel compounds produced by engineered microbial strains.

You will operate state-of-the-art analytical equipment (notably Orbitrap MS and NMR) and collaborate closely with scientists from chemistry, bioassay, and microbiology teams to solve structural questions and advance hits toward validation. You will work closely with Chloé, our chemist, and be in continuous interaction with the broader Chemistry & Bioassay team to coordinate compound characterization efforts.

Key responsibilities :

• Perform extraction, purification, and analytical characterization of bioactive compounds from microbial cultures.

• Operate, maintain, and optimize Orbitrap mass spectrometers, including method development and troubleshooting.

• Design and execute structure elucidation workflows combining MS, NMR (1D/2D), and orthogonal techniques.

• Integrate analytical data with biological readouts to support dereplication, hit triaging, and SAR generation.

• Document results clearly, contribute to IP filings, internal reports, and cross-functional discussions.

• PhD in analytical chemistry, natural product chemistry, or engineer/MSc with several years of relevant industry experience.

• Strong hands-on background in natural product isolation and analysis.

• Demonstrated expertise in Orbitrap MS: method development, daily operation, instrument maintenance.

• Solid experience in structure elucidation, especially using NMR, and in combining analytical approaches to solve structural challenges.

• Comfortable working with complex microbial extracts and low-abundance compounds.

• Collaborative and approachable, able to communicate clearly with colleagues from different scientific domains.

Enjoys working in a dynamic, fast-evolving research environment, with a mindset of curiosity and teamwork.

Why Join Us?

At Generare, you’ll join a passionate, interdisciplinary team committed to building the world’s largest industrial platform for the discovery of microbial natural products. We offer:

• A chance to contribute to deeptech innovation with global impact

• An internationally connected scientific environment

• A flexible, empowering culture grounded in collaboration and excellence

• A front-row seat in shaping the future of natural compound discovery

→ Send an email tochloe.puteaux@generare.bio to apply with your CV and a short note describing your fit for the role. We welcome applications from candidates with international academic or biotech backgrounds.