The Mission

DNA Script is looking for an Enzyme QC Scientist to strengthen the development and the production of its proprietary enzymes. You will join the enzyme production team composed of 8 scientists and be in charge of the QC activity under the supervision of the enzyme DSP team leader. You will be responsible for developing, optimizing, validating, and executing appropriate QC tests for enzyme release to support R&D, process development and research grade manufacturing. You will have to collaborate with other teams to ensure the successful technology transfer into manufacturing environment.

Responsibilities

• Develop and optimize analytical and biochemical assays for enzyme characterization, including HPLC, SDS-PAGE and Western Blot, UV/Vis and Fluorescence Spectroscopy (cuvette and multi-well plate), qPCR
• Help validation department to realize critical evaluation of test methods in order to define acceptance criteria and to establish test method validation protocol
• Conduct experiments to validate QC methods following the validation protocol established by the validation department
• Document and compare testing results against control/specification limits
• Oversee and/or lead laboratory investigations to evaluate out-of-specification and atypical results within QC test methods, including troubleshooting of invalids and monitoring method performance.
• Conduct experiments, interpret results, draw conclusions, and recommend options for future experiments to achieve project goals
• Support generation of WIs, SOPs, and reports for internal tracking, development processes and technology transfer.
• Present experimental results and data analysis at group meetings as directed
• Participate in routine maintenance and lab safety by following laboratory procedures and good laboratory practices

Qualifications and experiences

• Hold a Master/Engineer in the field of chemistry, biochemistry, genetics, cell biology or related field
• 4+ years of work experience in a Quality Control Laboratory
• QC analytical method development experience, including assay optimization, assay qualification and validation, assay transfer to production and documentation
• Strong knowledge of protein biochemistry
• Attention to detail
• Ability to learn new methods and systems
• Appreciate lab work in a dynamic and evolving environment
• Excellent oral and written communication skills in English, good level of French is a plus

Miscellanous

• Job located in Kremlin-Bicêtre (Paris area, 5 minutes from Porte d’Italie)
• Start Date: as soon as possible
• CDI

• Phone interview with manager
• Day Interview at the office with manager, cofounders, HR and the team
• References Check
• Timing: 2-3 weeks