Aqemia
Aqemia

Drug Hunter

Shrnutí práce
Plný úvazek
Paris
Plat: Neuvedeno
Několik dní doma
zkušenosti: > 4 roky
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Aqemia
Aqemia

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About Aqemia

Aqemia is a next-gen pharmatech company generating one of the world's fastest-growing drug discovery pipeline.

Our mission is to design fast innovative drug candidates for dozens of critical diseases.

Our differentiation lies in our unique quantum and statistical mechanics algorithms fueling a generative artificial intelligence to design novel drug candidates. The disruptive speed and accuracy of our technological platform enables us to scale drug discovery projects just like tech projects. Our endeavors are further underscored by prestigious partnerships with industry leaders, including prominent pharmaceutical companies, FrenchTech ecosystem, and esteemed investment funds.

About the team you’ll join

Within Aqemia’s drug discovery portfolio team, Drug hunters are the pillars of drug discovery projects, leveraging our unique technology to invent a next generation of drugs.

Objective of such projects is to invent therapeutic molecules (hits / leads) against a given target protein and related disease, leveraging our unique technology combining new Physics and Machine Learning algorithms.

Projects can be in collaboration with pharmaceutical companies to invent molecules for their targets, or within Aqemia internal project portfolio.

A project is run by a core team - ie a drug hunter, a project leader, plus part of a Chemist and Biologist - and relies on the technology and ways of working developed by Aqemia platform.

Your role as a drug hunter at Aqemia

  • Design / Generate in the computer small molecules to address a given therapeutic target, starting with drug-target affinity and selectivity, and adding other efficiency & safety properties within Aqemia or in collaboration with Pharma partners based on technology from Aqemia’s platform, experimental results from the project and literature from the project
  • Communicate in a concise and written way your hypotheses and work plan, so that they can be discussed and improved, incl. code with attention to robustness and reproducibility
  • Apply and test the baseline technology and ways of working developed by Aqemia’s platform: generative AI algorithms to invent molecules, properties prediction models, molecular dynamic techniques, …
  • Give systematic feedback to Aqemia’s technology platform in a structured and constructive way, based on your experience and project experimental results
  • Propose new ideas to advance the project and improve Aqemia’s technology to make it more precise, fast, scalable
  • Discuss Chemistry plan with CROs to optimize predictions of properties and ease of synthesis and test
  • Work hand-in-hand with Aqemia’s interdisciplinary team beyond your project team, incl. Machine Learning engineers, software engineers, computational chemists and theoretical physicists
  • Mentor more junior drug hunters

    • The competencies we are looking for

  • You have Ph.D. and post-doctoral experience as well as a track record of technical excellence as shown by peer reviewed publications
  • Inventorship status on patents is a great nice to have
  • You have 3+ years of pharma/biotech/CRO experience with a focus on computational chemistry or computational biology
  • You have hands-on experience in computational chemistry applied to drug discovery using state-of-the-art structure-based or ligand-based methods, including techniques such as virtual screening, molecular docking, structure-activity relationship analysis, multi-property optimization-based compound design
  • You have extensive knowledge of protein structures, functions and protein-ligand interactions
  • You have knowledge of computational chemistry packages: RDKIT, OpenMM, parmed, GROMACS, Ambertools, MDAnalysis, …
  • You have proficiency in small molecule ligand discovery (esp. SBDD) and cheminformatics techniques including protein homology modeling, small molecule docking and pharmacophore hypothesis, in silico virtual screening, QSAR and ADMET properties modeling, database searches, combinatorial library design, FEP based affinity predictions, molecular dynamics simulations, etc.
  • You are an object-oriented programmer coder who’s comfortable with object-oriented programming in Linux/UNIX environments. 
  • Intermediate to advanced python programming

    • Preferred mindset

  • You are eager to play an active role in contributing to Aqemia’s strategy to develop drugs for patients.
  • You are anxious to bring your wealth of knowledge and skills to the table to inspire and coach brilliant people from diverse backgrounds.
  • You are keen to solve tough problems on issues that truly matter, with a proactive and a can-do attitude.
  • You thrive on working collaboratively in a fast-paced, interdisciplinary environment that keeps everyone on track.

    • Our recruitment process

  • 1 - Hiring Manager’s interview: you’ll meet directly with your future manager Quentin (1h, visio call)
  • 2 - Technical assessment of your skills: questions around molecular modeling, medical chemistry, molecular docking and cheminformatics (1h, visio call)
  • 3 - Cultural fit interview with our co-founder and COO Emmanuelle (45min, visio call)
  • 4 - Final interview with our co-founder and CEO Maximilien (45min, visio call)

    • About us

    We work for a mission: joining us means having your own impact on changing the way drugs are discovered, and helping to shape the direction of our fast-growing company and team.

    - Our approach is completely unique in the industry, using AI & deep physics to discover new drugs.

    - We are a team of +50 people from world-class institutions (AstraZeneca, GSK, Sanofi, Harvard, Princeton, Ecole Normale Supérieure, Ecole Polytechnique, BCG...). 

    - We are also a multinational team: our working language is English.

    - Our founders boast : 10+ years of research experience at the Ecole Normale Supérieure in Paris, not to mention a stint at Oxford and Cambridge / 10+ years of strategy consulting experience at BCG.

    - We are part of the French Tech 2030 program (https://lafrenchtech.com/fr/la-france-aide-les-startup/french-tech-2030/).

    - We recently signed a $140 million contract with Sanofi to accelerate their drug discovery.

    - Global Series A fundraising of up to 60M€.

    What can we offer

    - Competitive salary and BSPCE policy

    - Hybrid remote working policy: 2 days/week can be worked remotely

    - Beautiful office in Paris, metro Pasteur (line 12)/Sèvres-Lecourbe (line 6)/Duroc (lines 13 & 10) - Montparnasse station less than 15 minutes walk.

    - Alan mutuelle, Swile lunch card

    - Transportation: green participation if you come by bike

    - If needed: a relocation package to move to Paris, including various services to help you get settled

    Tato volná pracovní místa by vás mohla zajímat!

    Tyto společnosti rovněž nabírají pracovníky na pozici "{profese}".

    • Aqemia
      Aqemia
      Aqemia

      Senior Drug Hunter

      Paris

      Plný úvazek
      Možnost pracovat částečně z domova
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