DNA Script

DNA Script is a leading company in manufacturing de novo synthetic nucleic acids using enzymatic DNA synthesis (EDS) technology. The company aims at accelerating innovation in life science and technology through the decentralization of rapid, on demand and high-quality DNA synthesis. DNA Script's approach leverages nature's billions of years of evolution in synthesizing DNA to set a new standard for customizing nucleic acid synthesis thus accelerating discovery in genetics, genomics, and synthetic biology. Discovery disciplines with profound impacts upon humanity such as biopharma, translational genetics and even molecular information storage all start with synthetic DNA. The company has recently initiated the commercialization of its first EDS powered platform, the SYNTAX system.

To date, DNA Script has raised over $315M of financing, with leading investors such as Coatue Management, Fidelity Management and Research, Catalio Capital Management, Casdin Capital, LSP, Bpifrance Large Ventures, Danaher, Illumina Ventures, Agilent, Merck Ventures, Sofinnova Partners, Kurma Partners, T Rowe Price, Baillie Gifford and Eurazeo.

DNA Script also partners on technology and product development with leading organizations such as DARPA, IARPA, Moderna Therapeutics, GE Research, Illumina, the Broad Institute, Harvard University, Institut Pasteur and the French Department of Defense.

DNA Script has its research and manufacturing facilities headquartered in Paris, France, and is in the process of expanding its commercial and development teams in South San Francisco.

Opportunity and Challenges :

We are looking to assemble a team of best-in-class, innovative and passionately eager people. We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write.” We offer the opportunity of joining a dynamic, international, and highly skilled team in a pioneering startup. Our DNA On Demand platform not only has the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impacts across biological sciences.

The role

DNA Script is actively searching for a Bioinformatics Scientist to provide bioinformatic support to a number of our teams.

The ideal candidate should be enthusiastic and passionate about bioinformatics and related technologies. We are looking for a team player, who can rapidly adapt to challenges, and interact with different teams as new projects arise. This position would be an excellent match for someone who is comfortable working with both biologists and developers to translate biological data into actionable insights.

We have many different teams within DNA Script who have bioinformatic requirements, and this role will include assisting in both the rapid turnaround of biological questions into insight, as well as running and maintaining already established pipelines and tools. Thus, the ability to juggle multiple projects, both short-term and long-term, is crucial.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.

Responsibilities

• Data Analysis of next generation sequencing (NGS) data
• Data interpretation and visualisation
• Developing and maintaining robust bioinformatic pipelines
• Provide bioinformatic support to scientists working on a range of different projects
• Report writing and taking part in team meetings and code review

Preferred experience

Qualifications and experience

Essential

• Either a MSc degree in bioinformatics with at least 2 years’ experience of working in a related field
• Or a PhD in a related field (bioinformatics, computational biology)
• Direct experience working with NGS data
• Knowledge and experience developing and maintaining bioinformatics tools in Python
• You will need to demonstrate a good level of expertise in Python and be experienced in the use common bioinformatic python-related technologies (pysam, pandas, conda, biopython)
• Comfortable working to a high standard both independently and as part of a team
• A strong background in using best-in-class tools and approaches to addressing bioinformatic problems (DNA-Seq, RNA-Seq)
• Curious and analytical, with a proven ability to learn quickly
• Proficient in English and a basic level of French

Desirable

• Data visualisation in R (ggplot, tidyverse)
• Experience in using workflow languages (snakemate, nextflow) to run pipelines
• Experience working in a cloud environment (e.g. AWS)
• Experience developing interactive tools using technologies such as Shiny
• Machine learning / Statistics
• Competence in working on a Linux command line
• Experience with Docker/Singularity is a plus

Recruitment process

1. Phone interview with the hiring manager
2. Day interview with manager, cofounders, HR and the rest of the team
3. References Check
4. Timing: 2-3 weeks