IDHwt Glioma /Glioblastoma (GBM) is the most common malignancy of the brain in adults and the most aggressive type due to its infiltrative growth pattern and heterogeneity.

One of our main challenges in developing new therapies for glioma is the lack of in vitro preclinical models that faithfully reproduce the properties of tumors in patients.

The candidate will constitute an organoid and patient-derived cell line biobank from fresh surgical tumor resection of glioma IDHwt patients. He/she will set up the best culture conditions to preserve the tissues and performed complex human-induced pluripotent stem cell (iPSC)-derived cerebral organoids for implementation of glioblastoma-coculture models. The candidate will define cellular integrity, heterogeneity and molecular characteristics using state-of-the-art technologies in immunohistochemistry, cytometry, imaging and multi-omics. The development of these relevant disease models will ultimately benefit to our drug discovery programs.

Main Responsibilities:

- Design and perform complex cellular studies

- Establish a biobank and implement relevant cellular models for in vitro pharmacology

- Make detailed scientific observations, analyze data, interpret and present results

- Collaborate with multidisciplinary teams (e.g. Oncology Therapeutic Area, US Research, Integrative Molecular Pharmacology, Translational Medicine, Research Support)

- Follow literature in the field

- Participate to associated projects in the group

- Communicate research data at internal events and participate to external meetings

- Participate to lab life and respect HSE rules

Description du profil :

Desired Profile:

Educational & professional Background:

• You have a PhD in Oncology or Cellular Sciences
• You have experience in cancer cell biology, biochemistry and pharmacology
• You have a proven research record and already performed conceptual work that resulted in a first author publication or is in the process of publishing

Hard Skills:

• Expertise in 3D culture and iPSC culture (GBM and/or brain cells is a plus)
• Expertise in imaging and flow cytometry
• Experience in clinical sample handling
• Experience in multi-omics is a plus

Leadership Skills:

• Ability to drive external collaboration for sample sourcing, and lead the project in a multi-disciplinary and international team environment with the willingness to share knowledge
• Ability to mentor and train research associates or students

Soft Skills:

• Excellent collaborative skills and ability to work effectively in multidisciplinary teams.
• Proactive, problem solving and decision-making skills.
• Perfect communication and presentation skills, both written and oral (French/English).