« Le contenu du poste est libellé en anglais car il nécessite de nombreuses interactions avec nos filiales à l’international, l'anglais étant la langue de travail. »  

Principal scientist, Pharmacology Laboratory head

Sanofi is a global health care leader that is transforming the oncology research and development paradigm. Our goal is to create a dynamic and exciting environment that is dedicated to cutting-edge science and delivering novel life-saving therapies to cancer patients. Our ability to execute on this vision depends on the knowledge, dedication, and innovation of employees throughout the organization. As a part of our team, you will have an opportunity to work with talented and passionate colleagues in Sanofi Oncology Research which is a global organization located in two sites: Cambridge, Massachusetts and Vitry-sur-Seine, France.

We are seeking a highly motivated, innovative & experienced scientist with a strong background and proven track record in the fields of oncology, immunology & pharmacology to join our team at our Vitry site. Significant experience with both small molecules and biologics is required. Experience with immune cell biology and cell assay techniques is required. The candidate will independently design and execute in vivo studies to evaluate new targets and advance new drug candidates in the Oncology portfolio. This will include developing and characterizing mouse models of cancer, designing and executing PK/PD and in vivo efficacy studies, and communicating/presenting ideas and data.

MAJOR DUTIES & RESPONSABILITIES

• Lead a team of 2 technicians provide management, scientific support and oversee the design and execution of in vivo studies to advance drug candidates through the pipeline of Sanofi’s Oncology portfolio
• Develop efficient interactions with collaborators within and outside Oncology
• Provide scientific expertise, establish, and monitor external scientific collaborations, monitor & provide critical assessment of competitor activities
• Recognize, assess, and implement scientific trends
• Participate in the development and characterization of novel mouse models for immunotherapy and molecular oncology, promote establishment, evolution and characterization of cancer models dedicated to drug discovery and development projects
• Provide and promote support for operational procedures according to Sanofi values, ethics and security
• Provide management and scientific support to train lab members and promote their career development
• Prepare publications, research, and clinical/regulatory documentation in accordance with Sanofi quality standards

REQUIRED EDUCATIONAL BACKGROUND AND JOB-RELATED EXPERIENCE

We are looking for a highly motivated individual with a Ph.D. in Oncology, Immunology or a related discipline, with 3-5 years of relevant experience in pharmaceutical industry drug discovery and development with a focus on in-vivo efficacy, pharmacology and PK/PD studies

• Scientific understanding of immunology, oncology, biology, biomarker and translatability between experimental models and human patients
• Experience and deep understanding of in-vivo mouse models (e.g. syngeneic, humanized and transgenic mouse models), ideally oncology and immuno-oncology, for the characterization of therapeutics
• Experience in multi-colour flow cytometry
• Strong conceptual understanding of basic cancer signalling pathways
• Strong experience working in a cross-functional organization
• Ability to plan and communicate complex studies in a fast-paced environment
• Excellent team leadership, organizational and management skills
• Excellent written and oral communication skills
• Fluency in English is essential

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.