Sanofi Vitry-sur-Seine est l’un des sites les plus innovants du Groupe, avec plus de 2 000 collaborateurs.​

Doté d’un outil de production ultramoderne, le Biolaunch, le site maitrise à la fois les activités de recherche, de développement et de fabrication de produits de biotechnologies.​

Les pathologies que nous traitons ? Le cancer, les maladies neurodégénératives et les maladies cardiovasculaires.

Le contenu du poste est libellé en anglais car il nécessite de nombreuses interactions avec nos filiales à l’international, l'anglais étant la langue de travail.

CONTEXT

The drug substance function within global Manufacturing Science & Technology (MSAT) is the owner of Life Cycle Management (LCM) of DS Processes within Sanofi biologics manufacturing network. We deliver innovative, robust, and cost-effective next generation processes and provide commercial manufacturing support. The function is responsible for tech transfer activities including process fit-gap assessment, process validation, prepare dossier sections, & PAI support to enable launch of new and LCM products. Our expansive portfolio covers 19 products, 5 modalities, 3 expression systems within 12 internal and external global sites in US and EU. We will be supporting launch of 20 new products in next 5 years including monoclonal and multi-specific antibodies, fusion protein, antibody-drug conjugate, synthorins and nanobodies. In recent years we have successfully established second-generation manufacturing process with continuous process platform. We are pursuing future innovations such as digital labs, factory of future and advanced analytics-based process understanding and control.

Head of Downstream at Vitry (France) will be part of global downstream team within global MSAT, Specialty Care Operation. Key responsibilities include:

• Manage a large group (8+) of scientists and engineers to support internal and external manufacturing. Routine activities include process monitoring and continuous versification, deviation and change control management, yield and process robustness improvement, annual report and inspection support, and lab experiments using scaled down model
• Lead Tech transfer, scale-up and facility fit, control strategy implementation, process validation, process comparability for internal/external new program launch, and manufacturing network expansion. Accountable for decisions at team functional level. Able to outline risk and uncertainties of complex topics to enable sound decision making
• Manage a lab function to provide small scale data support for technical investigation and improvement. Build the lab team and capability as needed
• Work with upstream, analytical, and other MSAT functions to support all aspects of LCM activities. Promoter of the use of Digital tools to engage with employees
• Work with quality, operation, regulatory, raw material, procurement, and other Sanofi teams to drive cross-function initiatives such as global guidelines for process validation strategy
• Work with internal research and Chemistry Manufacturing and Control team to guide late-stage development and control strategy implementation (including scale-up, process validation, and commercial launch). Able to implement transformation/change management at team/site/local MSAT level. Allocates resources at site/team level in alignment with functional and program priorities
• Work with HR and senior leadership to implement talent development principles and build a high-performance team. Actively participates in employee lifecycle from selection of talent, development of internal talent, and performance management of employees; effectively provides feedback and coaching to poor performers while differentially focusing on development of high performing/high potential employee. Advocate for talent at functional MSAT or site forums

CANDIDATE PROFILE

Skills

• Strategic Thinking: Makes decisions by analysing current and future scenarios. Disrupts the status quo with innovation, while remaining pragmatic and focused on priorities
• Result orientation: Executes, is comfortable with ambiguity, and adapts with agility. Takes calculated risks and anticipates potential issues
• People Leadership: Engages and leverages everyone’s strengths while being highly self-aware
• Relationship & Influence: Inspires trust through empathy and authenticity. Empowers and recognizes others to create powerful relationships and networks

Behaviours

• Stretch: Encourages the team to stretch and do things differently. Try new things and take calculated risks. Prioritize to deliver the most value
• Take Action: Sets a clear context and creates space for the team to take action. Focus on solutions and simplify the approach
• Act for Patients and Customers: Makes sure the team understands how to act for patients and customers. Actively engage with stakeholders and understand their needs
• Think Sanofi First: Approaches their role with humility and thinks Sanofi first. Share information openly and proactively, and help colleagues be successful

Qualifications

• Degree in life sciences, engineering, or other relevant discipline Bachelor Sciences/Master Sciences with 10+ years of professional experience, or PhD with 5+ years of professional experience
• Minimum of 5 years of Supervising a technical team in process development or manufacturing support
• English fluent

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.