Johnson & Johnson

Johnson & Johnson

Discovery Scientist Lead Evaluation and Cellular Pharmacology

  • CDI 
  • Aiguefonde
  • > 5 ans

Le poste

Discovery Scientist Lead Evaluation and Cellular Pharmacology

  • CDI 
  • Aiguefonde
  • > 5 ans

About

Chez Johnson & Johnson, ils pensent qu’une bonne santé est la base de vies plus dynamiques, de communautés prospères et de progrès. C’est pourquoi, depuis plus de 130 ans, leur objectif est de contribuer à aider les personnes à rester en bonne santé à tous les âges et à toutes les étapes de la vie.

Grace a une large gamme de produits au travers de trois entités – Janssen, Johnson & Johnson Santé Beauté France (JJSBF), Johnson & Johnson Medical Devices (JJMD) – Le groupe Johnson & Johnson s’engage à soutenir les personnes tout au long de leur vie et à adopter une approche globale des soins à travers la prévention, le diagnostic et la thérapie. Ils investissent dans la recherche et le développement pour améliorer la santé et le bien-être des personnes. Ils créent un environnement où la diversité des points de vue et les dialogues ouverts sont encouragés, permettant ainsi aux collaborateurs de se développer. En favorisant la collaboration entre les secteurs, entre les fonctions et avec des partenaires stratégiques, ils agissent comme une seule et même entreprise envers les communautés et le monde extérieur.

Ils comptent sur vous, sur vos idées et sur votre enthousiasme pour les aider à accomplir leur mission : implémenter de nouvelles idées afin d’améliorer la qualité de vie pour tous.

Chez Johnson & Johnson, travail et bien-être sont liés. Ambition et simplicité vont de pair.

Job description

The candidate will join the Lead Evaluation and Cellular Pharmacology team, to develop cutting-edge approaches for the identification of small molecule therapeutics for various disease indications, including Oncology, Immunology, Infectious Diseases, Neuroscience, and Cardiovascular and Metabolic Diseases. S/he will work in an exciting, interdisciplinary environment, across the different stages of lead discovery pipeline, by interacting with several internal and external groups. The candidate should be highly self-motivated and can work independently. Responsibilities for the candidate include design and execution of cellular experiments and assays for the identification and characterization of small molecules, antibodies, peptides and nucleotide-and cell-based therapeutics. The candidate is expected to be able to critically analyze data and troubleshooting skills will be essential. S/he should demonstrate a sense of urgency, independency, be organized and adhere to sensitive timelines.

The work location for the position is Beerse, Belgium 

 

Primary responsibilities

(include, but are not limited to):

  • Substantial hands-on work in designing, development, miniaturization and automation of cellular and biochemical experiments and assays
  • Collaborate with stakeholders and business partners from all relevant functions and take the lead for scientific and technical programs
  • Propose novel and actionable assay ideas, aligned with internal and external scientific strategies and demands
  • Contribute to the elaboration and the execution of new methodologies and strategies applied to high throughput screening and activity profiling of small molecules in miniaturized format
  • Keep up to date on literature related to his/her field. Act as an expert resource in her/his scientific field and related disciplines. Propose novel and actionable assay ideas, aligned with internal and external scientific strategies and demands
  • Interpret, troubleshoot and report on complex/multidimensional data
  • Present data in professional 'publication ready' format

Qualifications

Education: Ph.D. degree in Biology, Immunology, or Biochemistry or master’s degree with a minimal of 5 years of experience in drug discovery

Related Experience:

Required:

  • Ability to perform proper cell/tissue culture and experience in cellular and molecular biology techniques (e.g., microscopy, immunocytochemistry, flow cytometry, mass cytometry, transfections, transductions, RNAi and CRISPR/Cas9, qRT-PCR, western blotting, luminescence -based assays, cytokine assays, multiplex transcription assays)
  • Strong capabilities to collaborate with scientists in multiple disciplines. Scientific knowledge in one or more fields of Oncology, Neuroscience, Immunology, Infectious disease
  • Basic statistical knowledge and experience with data analysis software (e;g; Genedata Screener, FlowJo, Cytobank, Spotfire, Graphpad Prism)

Preferred:

  • Proven background in drug discovery with a track record of contributing to projects involving various target classes and technologies  
  • Experience with isolation and culturing primary cells and development of functional cellular assays
  • Experience with complex cellular systems (organoids, iPSc)
  • Experience with high throughput liquid handlers and lab automation
  • Expertise in high dimensional data analysis

Personal skills and Competencies:

  • Intellectually curious and well-informed on the latest scientific advances in the field
  • Demonstrates creativity and novel approaches to solving scientific problems
  • Works independently and towards high quality standards
  • Strong organizational skills including the ability to manage several projects simultaneously
  • Excellent interpersonal skills with the ability to interact effectively with people, internally and externally
  • Detail-oriented, with excellent record-keeping skills
  • Excellent oral and written communication skills. Able to effectively present scientific data and concepts to international standards.

Meet the team

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