DNA Script

DNA Script is a leading company in manufacturing de novo synthetic nucleic acids using enzymatic DNA synthesis (EDS) technology. The company aims at accelerating innovation in life science and technology through the decentralization of rapid, on demand and high-quality DNA synthesis. DNA Script's approach leverages nature's billions of years of evolution in synthesizing DNA to set a new standard for customizing nucleic acid synthesis thus accelerating discovery in genetics, genomics, and synthetic biology. Discovery disciplines with profound impacts upon humanity such as biopharma, translational genetics and even molecular information storage all start with synthetic DNA. The company has recently initiated the commercialization of its first EDS powered platform, the SYNTAX system.

To date, DNA Script has raised over $315M of financing, with leading investors such as Coatue Management, Fidelity Management and Research, Catalio Capital Management, Casdin Capital, LSP, Bpifrance Large Ventures, Danaher, Illumina Ventures, Agilent, Merck Ventures, Sofinnova Partners, Kurma Partners, T Rowe Price, Baillie Gifford and Eurazeo.

DNA Script also partners on technology and product development with leading organizations such as DARPA, IARPA, Moderna Therapeutics, GE Research, Illumina, the Broad Institute, Harvard University, Institut Pasteur and the French Department of Defense.

DNA Script has its research and manufacturing facilities headquartered in Paris, France, and is in the process of expanding its commercial and development teams in South San Francisco.

Opportunity and Challenges :

We are looking to assemble a team of best-in-class, innovative and passionately eager people. We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write.” We offer the opportunity of joining a dynamic, international, and highly skilled team in a pioneering startup. Our DNA On Demand platform not only has the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impacts across biological sciences.

The role

DNA Script is looking for a dynamic and talented intern to join the System Integration team, in charge of the development of new DNA synthesis process and instrumentation.

With the improvement of the quality of enzymatically synthesized DNA came the opportunity to go further in the applicative field.

The role will be to participate in the automation and optimization a gene assembly workflow on a liquid handling platform. The candidate’s goal will be to adapt existing gene assembly protocols to the platform, taking advantage of its built-in functionalities, or creating new ones if necessary. Ultimately, this platform will become an easy-to-use, flexible, and intuitive tool to optimize the assembly protocol in an efficient and robust way. The candidate must be handy, autonomous, and rigorous, with a detail-oriented mindset and an appetite for automation.

The position will require a lot of transversal and interdisciplinary communication with the different team members as well as with other teams to implement research protocols into future products.

This offer is an opportunity to join a rapidly growing company and to have a great opportunity of participating to the development of a new and revolutionary technology that will have far-reaching impact across biological sciences.

Responsibilities

Your missions will be:

• Maintaining and running an automated liquid handler,
• Writing scripts in order to implement new methods
• Fully automating existing and new gene assembly protocols on the liquid handling platform
• Designing experimentations for gene assembly workflow optimization, especially the steps that need specific adaptation for automation
• Contributing actively to product development
• Performing in depth analysis of experimental data
• Regularly writing reports and presenting results across all levels of the company
• Actively contributing to critical company milestones, with a willingness to work outside immediate area of expertise when required

Qualifications and experience

Essential

• M2 student in biomedical, biotechnology or automation in link with life science
• First experience in Life science R&D labs or diagnostic developing instrumentation or working on HTS platforms
• Knowledge in molecular biology and or biotechnology
• Willingness to work on automated system, such as Hamilton
• Coding skills (python, VBA )
• Excellent organizational, analytical, and systematic troubleshooting skills
• Ability to work as part of a multidisciplinary team
• Excellent English level
• Highly motivated and proactive
• Excellent communication and interpersonal skills

Desirable

• Good French speaking level
• Experience in molecular biology and in particular working with DNA
• Advanced coding skills
• Experience in working with liquid-handling robot
• Experience in process optimization

Miscellaneous

Job located in Kremlin-Bicêtre (Paris area) Start date: ASAP Contact: hiring@dnascript.co