DNA Script

DNA Script is a leading company in manufacturing de novo synthetic nucleic acids using enzymatic DNA synthesis (EDS) technology. The company aims at accelerating innovation in life science and technology through the decentralization of rapid, on demand and high-quality DNA synthesis. DNA Script's approach leverages nature's billions of years of evolution in synthesizing DNA to set a new standard for customizing nucleic acid synthesis thus accelerating discovery in genetics, genomics, and synthetic biology. Discovery disciplines with profound impacts upon humanity such as biopharma, translational genetics and even molecular information storage all start with synthetic DNA. The company has recently initiated the commercialization of its first EDS powered platform, the SYNTAX system.

To date, DNA Script has raised over $315M of financing, with leading investors such as Coatue Management, Fidelity Management and Research, Catalio Capital Management, Casdin Capital, LSP, Bpifrance Large Ventures, Danaher, Illumina Ventures, Agilent, Merck Ventures, Sofinnova Partners, Kurma Partners, T Rowe Price, Baillie Gifford and Eurazeo.

DNA Script also partners on technology and product development with leading organizations such as DARPA, IARPA, Moderna Therapeutics, GE Research, Illumina, the Broad Institute, Harvard University, Institut Pasteur and the French Department of Defense.

DNA Script has its research and manufacturing facilities headquartered in Paris, France, and is in the process of expanding its commercial and development teams in South San Francisco.

Opportunity and Challenges :

We are looking to assemble a team of best-in-class, innovative and passionately eager people. We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write.” We offer the opportunity of joining a dynamic, international, and highly skilled team in a pioneering startup. Our DNA On Demand platform not only has the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impacts across biological sciences.

The role

We are looking for a Senior Engineer in LC MS in the Analytics Team. His/her main mission will be to :

• Characterize impurities by LC HRMS, developping meanwhile new MS workflows for fine structure elucidation
• Manage analysis of oligonucleotides samples and the interpretation of the data,
• Take part to the standardization of lab practices (work instructions, reports, maintenance/ qualification program of the instruments)

The position reports to the Analytical Team Manager and will act as a point of reference for Mass Spectrometry in the team.

Responsibilities

• Develop, improve new and existing analytical methods for sample preparation (automation/ liquid handling robot, SPE…), for characterization of oligonucleotides and their related impurities by UPLC/HRMS, optimizing associated workflows for data treatment,
• Take part to the routine analyses program for oligonucleotides in medium and high throughput regarding MS to support the R&D projects,
• Interpret, validate the analytical results using a LIMS,
• Ensure maintenance and verification of the instruments; enforce their performance by standardizing their use (work Instructions; logbooks; system suitability tests),
• Write analytical development protocols and reports,
• Ensure communication with other teams,
• Guarantee bibliography review and state of the art techniques,
• Participate in the organization of the analytical laboratory

Preferred experience

Qualifications and experience

Essential

• Minimum Master of Science or equivalent Engineering degree: chemical engineer, biochemist or related, preferably in Analytical chemistry, bio-analyzes,
• At least 5 years of experience in analytical development using LC/MS on biomolecules,
• Mandatory experience in chromatography (UHPLC), High Resolution Mass Spectrometry and associated software
• Excellent communication and interpersonal skills,
• Ability to work independently and within a large multidisciplinary team,
• Dynamic with a positive attitude willing to commit to a high level,
• Good written and verbal communication skills in French and in English

Desirable

• Experience in the biotech/pharma industry,
• Start-up mindset.

Recruitment process

• Visio interview with the hiring manager
• Day interview at the office with the manager, cofounders, HR and the rest of the team
• Reference Checks
• Timing: 2-3 weeks