The role

DNA Script is looking for a talented individual to join the chemistry R&D team as Research Scientist - Nucleoside and Nucleotide Chemistry. The candidate will be responsible for synthesizing multiple types of modified nucleosides/nucleotides, one of the key reagents in DNA Script’s EDS technology, as well as participating in R&D projects to improve performance of enzymatic DNA synthesis technology. The position will report to the Modified Nucleotide Team Leader.

Responsibilities

• Conduct synthesis and purification of modified nucleosides and nucleotide through various chromatography (flash chromatography, ion exchange chromatography, reverse phase chromatography) methods and instrumentation
• Conduct analysis of modified nucleosides and nucleotides utilizing state-of-art analytical instruments, such as 1H/13C/31P NMR, HPLC and LC-MS
• Record detailed procedures and results in lab notebook and write technical documents, such as work instruction (WI), standard operating procedures (SOP)
• Prioritize and manage own work schedule to timely meet project milestones and deadlines
• Train and mentor junior team member
• Participate to the order and inventory of chemicals to maintain common stock in the chemistry laboratory
• Perform maintenance of certain equipment of the laboratory
• Perform other laboratory tasks assigned by Team Leader and Director of Chemistry
• Participate in chemistry R&D team meeting and present weekly technical report
• Maintain highest laboratory safety practice and keep the lab organized and tidy

Qualifications and experience

• Holds a PhD degree or Master degree in Organic Chemistry, Medicinal Chemistry or similar field with at least two years of industry experience
• Expertise in multi-step organic synthesis and purification with hands-on experience in nucleoside, nucleotide chemistry
• Expertise in various analytical and purification methods and instrumentation: pH meter, UV-Vis spectrometer, NMR, analytical and preparative HPLC, LCMS, thin-layer chromatography, flash column chromatography, ion exchange chromatography
• Excellent written, organizational, and documentation skills
• Excellent communication and interpersonal skills, efficient interaction with internal and cross functional team members
• Ability to work independently and as part of a large multi-disciplinary team
• Fluent English speaker

1. Phone interview with the hiring manager
2. Day interview with manager, cofounders, HR and the rest of the team
3. References Check
4. Timing: 2-3 weeks