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Bioinformatician

CDI
Le Kremlin-Bicêtre
Salaire : Non spécifié
Télétravail non autorisé

DNA Script
DNA Script

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Le poste

Descriptif du poste

The role

DNA Script is looking for a talented Bioinformatician to provide comprehensive bioinformatic support to its Application Development Team which is central to the development of the company’s core technology. Today, DNA Script’s Application Development Team main mission is to develop new innovative applications for our technology, involving the current use of sequence alignment, oligo design and Next Generation Sequencing (NGS) data, among others.

The candidate will be mainly in charge of leading the analysis and interpretation of high throughput sequencing datasets enabling the rapid evaluation of the applications under development. As such, the Bioinformatician will develop and apply bioinformatic methods and tools and perform tasks to help the Application team to interpret and prioritize their projects. In particular, the candidate will be in charge of developing:

  • Bioinformatic pipelines dedicated to the analyses of high throughput sequencing data
  • Tools for primer design

Bioinformatic analysis is central to the Application Development team therefore the candidate will need to interact with the different team members, understand their needs and develop the appropriate solutions.
We are looking for a person who is rigorous, methodical, well organized, detail-oriented, problem-solver and capable of playing a cross-functional role within a multidisciplinary team.


Profil recherché

Qualifications and experience

Essential

  • Master’s Degree/PhD in Bioinformatics or Senior Bioinformatician with 5+ years of significant computational experience related to bioinformatics work in academia, biotechnology, or other healthcare field involving next generation sequence data analysis
  • First-hand experience in NGS analysis and methods as well as the computing infrastructure and data management methods to support NGS
  • Perfect knowledge of:
    o Sequencing technologies and sound knowledge of the technical specificities inerrant to each of them (ie Illumina, PacBio, IonTorrent, Oxford Nanopore etc
    o Large dataset analysis in Python
    o Analyzing next generation sequencing data (DNA-seq, RNA-seq, etc.).
    o Building an NGS pipeline
    o Commonly used database and bioinformatics tools for NGS data analysis (e.g.) bedtools, SAMtools, IGV, ANNOVAR, Bowtie, GATK, ChimeraScan, UCSC Genome Browser, SoftGenetics, TopHat, etc.)
    o Proficiency in a scripting language (e.g. Python 3) and Unix environments
  • Knowledge about molecular biology and genomics, ability to translate a biological question into a mathematical model/analysis method
  • Proven experience and success in a team-oriented environment
  • Feel comfortable in a fast-paced work environment
  • Excellent level of English and good level of French

Desirable

  • First-hand experience at integrating publicly or commercially available genetic, genomic, and interaction datasets with novel experimental data to identify testable hypotheses
  • HTML/CSS, Javascript and SQL on NoSQL databases
  • Web framework (e.g. Django, etc)

Déroulement des entretiens

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area, 5minutes from Porte D’Italie)
  • Start date: ASAP

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