DNA Script

DNA Script is a leading company in manufacturing de novo synthetic nucleic acids using enzymatic DNA synthesis (EDS) technology. The company aims at accelerating innovation in life science and technology through the decentralization of rapid, on demand and high-quality DNA synthesis. DNA Script's approach leverages nature's billions of years of evolution in synthesizing DNA to set a new standard for customizing nucleic acid synthesis thus accelerating discovery in genetics, genomics, and synthetic biology. Discovery disciplines with profound impacts upon humanity such as biopharma, translational genetics and even molecular information storage all start with synthetic DNA. The company has recently initiated the commercialization of its first EDS powered platform, the SYNTAX system.

To date, DNA Script has raised over $315M of financing, with leading investors such as Coatue Management, Fidelity Management and Research, Catalio Capital Management, Casdin Capital, LSP, Bpifrance Large Ventures, Danaher, Illumina Ventures, Agilent, Merck Ventures, Sofinnova Partners, Kurma Partners, T Rowe Price, Baillie Gifford and Eurazeo.

DNA Script also partners on technology and product development with leading organizations such as DARPA, IARPA, Moderna Therapeutics, GE Research, Illumina, the Broad Institute, Harvard University, Institut Pasteur and the French Department of Defense.

DNA Script has its research and manufacturing facilities headquartered in Paris, France, and is in the process of expanding its commercial and development teams in South San Francisco.

Opportunity and Challenges :

We are looking to assemble a team of best-in-class, innovative and passionately eager people. We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write.” We offer the opportunity of joining a dynamic, international, and highly skilled team in a pioneering startup. Our DNA On Demand platform not only has the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impacts across biological sciences.

The Role

Within DNAScript, the synthesis platform has several missions

• Synthesis of oligonucleotides for internal or external partners
• Assessment of new protocol performances and guarantee of process robustness
• Optimization of post synthesis processes (PSP)
• Functional characterization of synthetized oligonucleotides

We are looking for a Synthesis Platform Bioengineer, who will be in charge of organizing the activity of the synthesis platform team and guarantee the quality of the synthesized products and data delivered.

Main Responsibilities

• Understand and run synthesis and post synthesis processes on all the platform instrumentation
• Organize the platform’s activity to accommodate priorities of requests, as well as optimal use of the liquid handling device and synthesis instrumentation,
• Interact with many teams to better understand their needs, provide best synthesis configuration integrating the platform constraints.
• Analyze critically the synthesis results, consolidate data across the Synthesis platform runs in order to provide reliable and reproducible of data
• Prepare run and analyze the synthesis results for external collaborators. Prepare the samples for shipment along with the QC report of these oligonucleotides.
• Manage reagents and consumables stocks, as well as reagent and consumable traceability though out the platform synthesis process
• Ensure good usage and maintenance of the platform instrumentation
• Write Work Instructions, SOPs and reports for internal tracking, development processes and technology transfer to the Product Development Team
• Regularly present and report across all levels of the company.
• Actively contribute to critical company milestones, with a willingness to work outside immediate area of expertise when required.

Experience

• Master, Engineering degree in the field of molecular biology, biochemistry, biotechnology
• Experience in working/running a service platform
• Fluent in both French and English
• Excellent organizational, analytical, and systematic troubleshooting skills
• Experience in automation
• Down-to-earth mindset focused on finding simple solutions to complex problems.
• Extremely rigorous with a very high attention to details.
• Ability to work as part of a multidisciplinary team. Excellent communication and interpersonal skills.
• Highly motivated and proactive

Miscellaneous

• Permanent position
• Job located in Kremlin Bicêtre, France
• Start date: As soon as possible.

Recruitment Process

• Initial screening with the hiring manager
• Day interview at the office (or remote) with the manager, cofounders, HR and the rest of the team
• Reference Checks
• Timing: 2-3 weeks