Le contenu du poste est libellé en anglais car il nécessite de nombreuses interactions avec nos filiales à l’international, l'anglais étant la langue de travail.  

In the race for the future of health – The Sanofi mRNA Center of Excellence (CoE) 

At Sanofi, we chase the miracles of science, and we know mRNA has a role to play in the future of health. And while the pandemic has shaken up our industry, creating new opportunities and risks, we believe the acceleration of innovation with mRNA technology means vaccines and treatments for more people faster than before.

That’s why we’re looking for bold, optimistic world-changers to join our mRNA Center of Excellence. We’re investing €400m a year into the new Center, hiring a team of 450 dedicated employees, and focusing on implementing an integrated end-to-end mRNA vaccine capabilities and research with R&D, digital and CMC teams.

Bring your ambition and optimism and join us on our journey to discover and deliver transformative medicine to patients through the advancement of our cutting-edge mRNA technology! 

About the Opportunity  

As an experienced Senior Associate Scientist in human immunology, you will participate in designing, optimizing, and executing exploratory assays for Phase 1 and Phase 4 clinical studies supporting mRNA vaccine research and development.  

POSITION OVERVIEW 

The Biomarker Research unit in the mRNA Center of Excellence is building a world-class translational research team and is seeking highly motivated Senior Associate Scientist interested in exploratory assays to assess the immunogenicity, reactogenicity, and MoAs of mRNA vaccines in Phase 1 and Phase 4 clinical trials.  

The candidate should have a strong foundation in immunology and vaccinology as well as significant working experience with standard immunological laboratory techniques, such as cytometry, multiplexing technologies to quantify cytokines and antibodies, ELISAs, ELISPOT, cell freezing/thawing. The successful candidate will have the ability to learn and innovate immunological assay techniques and methodologies. The candidate will be expected to create experimental plans, implement in vitro assays, perform assays, as well as prepare reports and present results.

The candidate should remain up to date on the relevant scientific literature related to clinical exploratory immunology.  

The candidate will be ready to hit the ground running in a fast-paced environment that rewards personal initiative, collaboration, and scientific excellence.  

KEY RESPONSIBILITIES  

• Support execution on in vitro immunological and cellular assays to evaluate the biological functions of mRNA vaccine candidates in human immune cells 
• Develop and execute innovative and novel immunosorbent, FACS, ELISAs, ELISPOT, neutralization, and multiplex bead array assay methods 
• Devising new protocols and/or strategies to solve complex problems or optimize assays for stronger performance 
• Support the clinical exploratory protocol development and associated clinical documentation 
• Effectively record and report experiments, maintaining GRP and HSE standards and policies 
• Collaborate on project experimental study plans, reports, presentations, publications, and patents 
• The position requires work with human blood products  

CANDIDATE PROFILE 

Basic Qualifications  

• MSc with 1 year experience in immunology, biomedical, or applied science field 
• Knowledge of in vitro immunoassays, immunology, model systems, human infectious diseases, vaccine discovery, and/or multivariate datasets is preferred 
• Excellent communication, scientific writing, and presentation skills 
• Ability to support preparation of results into visually appealing and understandable stories 
• Understanding of clinical research and drug/vaccine discovery and development processes is a plus 

#mRNA  

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.