DNA Script

DNA Script is a leading company in manufacturing de novo synthetic nucleic acids using enzymatic DNA synthesis (EDS) technology. The company aims at accelerating innovation in life science and technology through the decentralization of rapid, on demand and high-quality DNA synthesis. DNA Script's approach leverages nature's billions of years of evolution in synthesizing DNA to set a new standard for customizing nucleic acid synthesis thus accelerating discovery in genetics, genomics, and synthetic biology. Discovery disciplines with profound impacts upon humanity such as biopharma, translational genetics and even molecular information storage all start with synthetic DNA. The company has recently initiated the commercialization of its first EDS powered platform, the SYNTAX system.

To date, DNA Script has raised over $315M of financing, with leading investors such as Coatue Management, Fidelity Management and Research, Catalio Capital Management, Casdin Capital, LSP, Bpifrance Large Ventures, Danaher, Illumina Ventures, Agilent, Merck Ventures, Sofinnova Partners, Kurma Partners, T Rowe Price, Baillie Gifford and Eurazeo.

DNA Script also partners on technology and product development with leading organizations such as DARPA, IARPA, Moderna Therapeutics, GE Research, Illumina, the Broad Institute, Harvard University, Institut Pasteur and the French Department of Defense.

DNA Script has its research and manufacturing facilities headquartered in Paris, France, and is in the process of expanding its commercial and development teams in South San Francisco.

Opportunity and Challenges :

We are looking to assemble a team of best-in-class, innovative and passionately eager people. We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write.” We offer the opportunity of joining a dynamic, international, and highly skilled team in a pioneering startup. Our DNA On Demand platform not only has the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impacts across biological sciences.

The Role

Within DNA Script, the Synthesis Platform Team is in charge of synthesizing oligonucleotides for various molecular biology applications, as well as validating new reagents and new analytical methods for manufacturing.

As part of the company expansion moving towards commercialization, reagent manufacturing is scaling-up and therefore reagent product development is becoming a full-time activity with a dedicated reagent product development team performing for example stability studies, ensuring second providers, improving packaging and cost. The reagent product development team is being currently staffed.

Therefore, DNA Script is looking for a Product Development Bioengineer for Enzymatic DNA Synthesis.

The candidate will be responsible for ensuring a smooth transition from R&D to manufacturing by running reagent stability tests, reagents guard banding tests, reagent packaging tests by mainly performing enzymatic synthesis on a liquid handler, analyzing and documenting the results, for all the reagents involved in enzymatic DNA synthesis (such as buffers, enzymes, nucleotides).

He/she will be collaborating with the R&D team, the manufacturing team and the QC team and will be directly involved in the reporting of DNA Script product performances and contribute to their improvement. The position will require a lot of transversal and interdisciplinary communication mostly with the manufacturing team in France and US, the R&D synthesis team and the QC team.

Main Responsibilities

• Perform all synthesis required for Reagent Product development for reagents produced both in house and by external partners
• Run those synthesis, based on appropriate protocols, on automated devices (liquid handlers), and thus be responsible for their maintenance and good performances
• Analyze the results, write the necessary documentation in order to transfer efficiently to manufacturing the new processes and formulations
• Ensure compliance with safety and quality standards compatible with ISO 13485
• Communicate the results to the Manufacturing team in order to transfer the new reagent batches or packaging
• Manage the long term stability studies for the new formulations
• Work with the QMS team to help develop and maintain all required documentation
• Manage the transfer of new synthesis protocols from the R&D validation system to the manufacturing scale
• Engage in good laboratory/documentation practices, write Standard Operating Procedures (SOPs) and enforce their correct use.
• Regularly present and report across all levels of the company.
• Actively contribute to critical company milestones, with a willingness to work outside immediate area of expertise when required.

Qualifications and Education Requirements

• Master or Engineering degree in the field of molecular biology, biotechnology or quality
• 1 to 2 years of experience in a biotech laboratory or similar role
• Understanding of manufacturing processes and quality/safety regulations (ISO 13485, BPL/GLP BPF/GMP or 21 CFR Part 820)
• Fluent in French & Professional Level of English

Preferred Skills and Abilities

• Willingness to work on liquid handlers, such as Tecan Evo, Hamilton Vantage
• Down-to-earth mindset focused on finding simple solutions to complex problems.
• Excellent organizational, analytical, and systematic troubleshooting skills.
• Rigorous with a high attention to details.
• Ability to work as part of a multidisciplinary team. Excellent communication and interpersonal skills.
• Highly motivated and proactive
• Experience in using liquid handling systems
• Experience in nucleic acid synthesis
• Experience in process optimization

Miscellaneous

• Job located in Kremlin Bicêtre (94) – Ile de France – Metro Line 7
• Start date: As soon as possible

Recruitment Process

• Initial screening with the hiring managers
• Day interview at the office (or remote) with the manager, cofounders, HR and the rest of the team
• Reference Checks
• Timing: 2-3 weeks

Contact

hiring@dnascript.co