DNA Script

DNA Script is a leading company in manufacturing de novo synthetic nucleic acids using enzymatic DNA synthesis (EDS) technology. The company aims at accelerating innovation in life science and technology through the decentralization of rapid, on demand and high-quality DNA synthesis. DNA Script's approach leverages nature's billions of years of evolution in synthesizing DNA to set a new standard for customizing nucleic acid synthesis thus accelerating discovery in genetics, genomics, and synthetic biology. Discovery disciplines with profound impacts upon humanity such as biopharma, translational genetics and even molecular information storage all start with synthetic DNA. The company has recently initiated the commercialization of its first EDS powered platform, the SYNTAX system.

To date, DNA Script has raised over $315M of financing, with leading investors such as Coatue Management, Fidelity Management and Research, Catalio Capital Management, Casdin Capital, LSP, Bpifrance Large Ventures, Danaher, Illumina Ventures, Agilent, Merck Ventures, Sofinnova Partners, Kurma Partners, T Rowe Price, Baillie Gifford and Eurazeo.

DNA Script also partners on technology and product development with leading organizations such as DARPA, IARPA, Moderna Therapeutics, GE Research, Illumina, the Broad Institute, Harvard University, Institut Pasteur and the French Department of Defense.

DNA Script has its research and manufacturing facilities headquartered in Paris, France, and is in the process of expanding its commercial and development teams in South San Francisco.

Opportunity and Challenges :

We are looking to assemble a team of best-in-class, innovative and passionately eager people. We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write.” We offer the opportunity of joining a dynamic, international, and highly skilled team in a pioneering startup. Our DNA On Demand platform not only has the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impacts across biological sciences.

The Role

DNA Script is looking for a R&D DSP Engineer to strengthen the development and the production of its proprietary enzymes. You will join the enzyme process team composed of 9 scientists and be in charge of the purification activity under the supervision of the DSP team leader. You will be in charge of optimizing the purification process of different enzymes at different scale in order to increase the purification yield of those enzymes. You will have to collaborate with other teams, especially enzyme engineering team, to develop and improve DNA Script technology.

Responsibilities

• Supervise one DSP Technician
• Manage operational activities of purification area (production and optimization)
• Identify and implement new downstream technology/instrumentation for continuous improvement of yield and throughput
• Develop robust downstream process and support process transfer to external partners
• Define strategy for the development, scale-up and optimization of the DSP process for multiple enzymes
• Conduct experiments, interpreting results, drawing conclusions and recommending options for future experiments to achieve project goals
• Support generation of WIs, SOPs, batch records and reports for internal tracking, technology transfer and development processes.
• Recognize and resolve technical problems and evaluate options for complex experimental problems
• Participate in routine maintenance and lab safety by following laboratory procedures and GLP

Qualifications and experiences

• Hold a Master/Engineer degree or PhD preferably in biochemistry, protein purification, biotechnology or related fields
• 6+ years of experience in proteins purification
• Extensive theoretical knowledge and hands-on experience with chromatography techniques
• Industrial experience in purification scale-up at pilot/commercial scale
• Demonstrated experience with managing multiple development projects in parallel
• Excellent oral and written communication skills in English, good level of French is a plus
• Proactive with excellent team spirit
• Appreciate lab work in a dynamic and evolving environment

Miscellanous

• Job located in Kremlin-Bicêtre (Paris area, 5 minutes from Porte d’Italie)
• Start Date: as soon as possible

Recruitment Process

• Initial screening with the hiring manager
• Day interview at the office with the manager, cofounders, HR and the rest of the team
• Reference Checks
• Timing: 2-3 weeks