The role

The Research Scientist - Nucleoside, Nucleotide and oligonucleotide Chemistry will be a part of Chemistry R&D team focusing on the continued research and development of DNA Script’s Enzymatic DNA Synthesis (EDS) technology to enhance synthesis protocols, enable customer applications, and improve product performance. You will report to the Director of Chemistry.

Responsibilities

• Collaborate with all the functions within the company to improve Enzymatic DNA Synthesis performance and advance our technology
• Design and execute synthesis of modified nucleotides with additional functionalities to broaden DNA Script’s EDS technology applications
• Develop in-house nucleoside phosphoramidite chemistry and automated oligonucleotide synthesis capacity
• Accurately document experiments and results in laboratory notebooks in a timely fashion
• Prepare and present experimental plans, results, and reports in R&D meetings
• Contribute to the development of the DNA Script patent portfolio and the scientific literature
• Maintain good laboratory and safety practices

Experience and skills

Essential:

• Holds a PhD degree in Organic Chemistry, Medicinal Chemistry or similar field with extensive training and practical laboratory experience in multi-step organic synthesis
• Experience in nucleoside, nucleotide synthesis and purification
• Preferred experience with nucleoside phosphoramidite chemistry and automated oligonucleotide synthesizer
• Hands-on experience in modern isolation, purification, and analytical techniques: Flash chromatography, Analytical and preparative HPLC, LC/MS, 1H/31P NMR, UV-Vis
• Strong publication record demonstrating ability to conduct research projects independently and collaboratively
• Excellent written, organizational, and documentation skills
• Excellent communication and interpersonal skills, efficient interaction with internal and cross functional team members
• Fluent English speaker

Miscellaneous

• Job located in Kremlin-Bicêtre (Paris area), please submit your resume and cover letter in English with your application
• Start date: ASAP

• Phone interview with manager
• Day Interview at the office with manager, cofounders, HR and the team
• References Check
• Timing: 2 to 3 weeks